Wastewater Basics 101 Major Focus - What . ized by elevated serum ammonia levels and manifests with hypotonia, seizures, emesis, and abnormal neurologic changes (including stupor). These different modes of action all may contribute to decreased condition, decreased growth, altered behavior and increased susceptibility to other stressors in affected biota. The reason is that the ammonia test (probe or reagent method) does not measure the potentially large contribution from organic nitrogen compounds (e.g., amines) in the wastewater. Nitrification will continue to occur at alkalinity levels below 40 ppm (as CACO3), though the optimum range is below 100 ppm. Advertising on our site helps support our mission. Newborns who have a complete deficiency in one of the urea cycle enzymes typically develop acute hyperammonemia within 24 to 72 hours of being born. the nitrification process in a non-emergency situation. At non-toxic concentrations, ammonia acts as a nutrient and can stimulate microbial and plant production (see the nutrient module for more information on these pathways). in: Muller R, Lloyd R (Eds). rates and at lower nutrient levels, essentially starvation or stationary growth conditions. Pressure around the brain (intracranial hypertension). In addition, some leachate samples were stripped of ammonia and used to help identify effects due to ammonia. Ammonia pollution is a key consideration in all of these. 1998). People who experience symptoms of high blood ammonia levels, such as sudden confusion, fatigue, or unconsciousness, should have their ammonia levels tested. This causes a buildup of ammonia in the blood that eventually travels to the brain, causing confusion and disorientation. Aquatic Toxicology 73:31-43. out - Organic matter, nitrogen, & phosphorus Minor Focus - Individual and small community wastewater treatment systems Wastewater basics are universal Independent of scale Nitrite-oxidizing bacteria (NOB) oxidize nitrite to nitrate (NO3-). High ammonia levels are life-threatening and require immediate medical treatment. Conceptual diagrams are used to describe hypothesized relationships among sources, stressors and biotic responses within aquatic systems. Environmental stresses like high temperatures may also lead to a reduction in the amount of dissolved oxygen in the water, which will invariably cause an increase in BOD readings. In more severe cases, dialysis or a liver transplant may be necessary. National Organization for Rare Disorders. They may diagnose hyperammonemia in adults if blood ammonia levels are above 30 micromol/L. Channel alteration can increase ammonia concentrations in several ways. Temperature also affects the toxicity of ammonia to aquatic life. 2 steps. It can cause loss of brain function and even death. It is important to speak with your provider to understand the meaning of your specific results. Timed samples were then collected at the downstream portion of the reach, and the data from all 11 regions were compared. However, the most common problems associated with ammonia relate to elevated concentrations affecting fish growth, gill condition, organ weights and hematocrit (Milne et al. Dialysis, a procedure to remove waste products from the blood when the kidneys stop working, may also be used when ammonia levels are extremely high, to remove excess buildup. The AIChE online library includes articles, journals, books, blog posts, and more on a variety of topics. www.waterworld.com is using a security service for protection against online attacks. The service requires full JavaScript support in order to view this website. Science of the Total Environment 170:71-79. Wastewater Nitrogen, as ammonia, is a critical nutrient in biological wastewater treatment. A fainter hot spot exists over a complex of geothermal power plants in California. We leverage the power of naturally sustainable microbial solutions to effectively solve problems for people and the planet without sacrificing quality or performance. Since hyperammonemia can damage your central nervous system and be life-threatening, your provider may also order imaging tests to look for complications affecting your brain, such as neuroimaging with a CT (computed tomography) scan or MRI (magnetic resonance imaging). Ammonia, also known as NH3, is a waste product that bacteria in your intestines primarily make when digesting protein. High ammonia levels in the blood are most often caused by liver disease. In an age where sustainability, resource recovery, and the circular economy are essential social themes, this article describes methods to remove, recover, and recycle ammonia from wastewater particularly wastewater streams from anaerobic digestion processes and landfill leachate. Eliminate a chemical feed and simplify your operation. Higher than normal blood ammonia levels are called hyperammonemia. This standard text in limnochemistry provides a good explanation of the chemistry of ammonia in surface waters. Luckily, high ammonia levels are usually fixed by performing multiple water changes. influent high TOC, high amine levels. Diseases of Aquatic Organisms 3:159-167. In many countries, including the U.S., authorities classify ammonia as an extremely hazardous substance. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140721). Algae and macrophytes take up ammonia, thereby reducing aqueous concentrations. Figure 1. People and newborns with untreated hyperammonemia or who receive delayed treatment have a high mortality rate due to irreversible brain swelling. This buildup can be fatal. During one-week storage, the urea nitrogen component in the fresh urine is hydrolyzed into high-strength ammonium with pH increased to above 9.0, which jointly led to a high FA level. For example, Na+ efflux rates are elevated in the presence of ammonia, and fish must increase Na+ influx to remain in Na+ balance. Ammonia generated in sediment may be toxic to benthic or surface water biota (Lapota et al. Lindsey Desoto is a licensed, registered dietitian and experienced medical writer. This module addresses ammonia as a proximate stressor with a toxic mode of action. Nutrient deficiency may also cause the production of viscous foam, and impact the jelly-like consistency of the activated sludge which will interfere with the sludge compaction (this is referred to as slime bulking). Hyperammonemia is a metabolic condition that happens when you have elevated levels of ammonia in your blood. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://labtestsonline.org/tests/ammonia), (https://medlineplus.gov/lab-tests/ammonia-levels/), (https://www.ncbi.nlm.nih.gov/books/NBK557504/), Visitation, mask requirements and COVID-19 information, Pathology & Laboratory Medicine Institute (R. Tomsich). Industrial emissions are responsible for 158 hot spots, primarily locations that produce ammonia-based fertilizers (4). c. Nitrification ceases at DO levels of less than 0.5 mg/L. Having high levels of ammonia in your blood is toxic to your central nervous system (CNS) (brain and spinal cord). This is not meant to be a comprehensive bibliography of references dealing with ammonia, but rather is meant to highlight a few references that may be especially useful. Nitrobacter then oxidize the nitrite to nitrate. Figure 5. The main test that healthcare providers use to diagnose hyperammonemia is a blood test that measures blood ammonia levels. Save time and your sanity know where to look for pressure-relief system design information. Because they obtain less energy during their metabolic processes compared to more common heterotrophic wastewater bacteriawhich require organic carbon for growththeir cellular growth is slower. Many human activities and land uses also decrease riparian and watershed vegetation, which may decrease the amount of nitrogen taken up by terrestrial plants, and further reduce channel complexity due to reduced woody debris inputs. Normally, ammonia is processed in your liver, where its transformed into another waste product called urea. First, it is a cause, such as through agricultural practices. As a general conclusion, it appears that emissions generated from human activities dominate natural ones. 2016;11(10):1872-1878. doi:10.2215/CJN.01320216. Medical treatment for hepatic encephalopathy involves decreasing the production of ammonia in your gut. Entrepreneurship is 10% idea, 10% luck, and 80% perseverance and grit, says Ryan Chan, founder of the mobile application UpKeep, which aims to transform the way that industrial plants run their facilities. The ammonia-selective electrode uses a hydrophobic gas-permeable membrane to separate the sample solution from an electrode internal solution of ammonium chloride. An official website of the United States government. Hence, effects are more likely to occur during seasons when early life stages are present. This is typically done with high volumes of product added daily over a week-long period until ammonia levels stay down, while work is done simultaneously to identify and correct the issue that caused the upset in the first place. Comparative Biochemistry and Physiology, Part B 121:99-109. It can be life-threatening and requires immediate medical treatment. The relative contribution of unionized versus ionized forms to total ammonia concentrations depends on certain water quality criteria, most notably pH: as pH increases, so does the proportion of ammonia in its unionized form. This document thoroughly discusses the basic properties, sources, and effects of ammonia to the aquatic environment of Canada. inhibitors, process chemicals and raw materials, or cleaning chemicals containing quaternary ammonium compounds. Wildlife Its easy to request permission to reuse content. Diamond J, Mackler D, Rasnake W, Gruber D (1993) Derivation of site-specific ammonia criteria for an effluent-dominated headwater stream. The net effect is that it takes 4.5 mg of oxygen to fully oxidize one mg of ammonia-N. Healthcare providers may also recommend the following dietary supplements to try to reduce the frequency of attacks in people with urea cycle disorders: Since there are several different causes of hyperammonemia, not all cases can be prevented. The cold weather only makes this worse by heavily slowing down the growth of the bacteria. The IDEAL path to equity, diversity, & inclusion. You must be logged in to view this content. For more information on specific entries, go to the When to List tab. In contrast, plant material is typically low in nitrogen, and associated decomposers may take up ammonia and reduce its aqueous concentration. Its especially important to be aware of these symptoms if you have liver disease since it can lead to elevated ammonia levels. It works by pulling ammonia from the blood into the colon, where it is removed through the stool. Headquartered in Bowling Green, Ohio, EnviroZyme is a world leader in the bioaugmentation industry. A lock (LockA locked padlock) or https:// means youve safely connected to the .gov website. Testing involves taking a blood sample with a needle from a vein in your arm and sending it to a laboratory. Xifaxan (rifaximin), an antibiotic, is often prescribed for high ammonia levels because it can help reduce ammonia made in the intestines and improve brain function. Environmental Toxicology and Chemistry 19(12):2929-2936. You just have to complete the following steps. Please enable JavaScript on your browser and try again. Also, BOD must be removed before Cleveland Clinics Robert J. Tomsich Pathology & Laboratory Medicine Institute touches virtually every patient at Cleveland Clinic and thousands of patients across the world. Last reviewed by a Cleveland Clinic medical professional on 04/11/2022. These sugars decrease the production and absorption of ammonia in your intestines. The resulting dissolved oxygen reductions can decrease species diversity and even cause fish kills. Such a high concentration in water may cause various health impacts on organisms, e.g., making fish susceptible to diseases . Hyperammonemia is a condition that happens when you have high levels of ammonia in your blood. MedlinePlus. Ammonia is one of the most commonly produced chemicals globally. The answer is simple, high nitrate in the effluent is very normal for biological process using aerobic process. Clement B, Merlin G (1995) The contribution of ammonia and alkalinity to landfill leachate toxicity to duckweed. An increase in pH favors formation of the more toxic unionized form (NH3), while a decrease favors the ionized (NH4+) form. Figure 2. High ammonia levels (hyperammonemia) can lead to symptoms including headache, vomiting, coma, and, in some cases, even death. Please note, however, that observation of these effects does not confirm a causal relationship. An elevated blood ammonia level, also known as hyperammonemia, is the accumulation of the waste compound ammonia in the bloodstream. is . Sources associated with urban and suburban development include fertilizers applied to golf courses and lawns; human wastes from sewer and septic systems and wastewater treatment plants; landfill wastes; and nitrogenous vehicle emissions. Ammonia, also known as NH3, is a waste product that bacteria in your intestines primarily make when digesting protein. Complications include: If a person has chronic mild hyperammonemia, they may develop an intellectual disability and permanent behavioral and psychiatric issues. Ammonia-oxidizing bacteria (AOB) oxidize ammonium ions (NH4+) to nitrite (NO2-). What should you do about it? Screening in these situations should be supplemented with measures of ammonia concentrations. Several conditions can cause high ammonia levels in your blood, including liver disease, kidney failure and certain congenital conditions. Once the required data are entered, the tool will calculate the amount of unionized ammonia in both mg/L and g/L. Early life stages of fish are more sensitive than juveniles or adults. Webster J, Swank W (1985) Within-stream factors affecting nutrient transport from forested and logged watersheds. it . Completion of the treatment process in many systems requires its removal A flood control impoundment along Los Gatos Creek in Campbell, CA. a. Treatment of acute hyperammonemia focuses on decreasing the level of ammonia and controlling specific complications, including brain swelling (cerebral edema) and pressure around the brain (intracranial hypertension). in wastewater and how do we get . Eighty-three of those hot spots arise from agricultural activity that involves large numbers of cows, pigs, and chickens. Some labs may also use different measurements. Xylomes novel technology enables recovery of a palm oil biosimilar from stillage waste byproducts. Removal of ammonium and orthophosphates from reject water generated during dewatering of digested sewage sludge in municipal wastewater treatment plant using . We do not endorse non-Cleveland Clinic products or services. The treatment for hyperammonemia depends partly on whats causing it, such as liver disease or hepatic encephalopathy in adults or a urea cycle disorder (UCD) in newborns. Hereditary urea cycle abnormality. For people who have severe hepatic encephalopathy due to hyperammonemia, the survival probability at one and three years has been reported to be 42% and 23%, respectively. 2000). 2000). In addition to observations of the sources discussed above, observational evidence at the site may suggest that high ammonia should be included as a potential candidate cause: Slow-moving water: Slow-moving or stagnant water (see Figure 5) may have high ammonia concentrations because of lack of turbulence and volatilization and greater accumulation of metabolic waste and decomposition productsincluding ammonia (WHO 1986). Ammonia then diffuses through the membrane and changes the internal solution pH that is sensed by a pH electrode. The level of ammonia in your blood must remain very low. How do high ammonia levels make you feel? If you or someone you know is experiencing symptoms of high ammonia levels, seek emergency medical attention. Last reviewed by a Cleveland Clinic medical professional on 08/24/2022. Excessive filaments and excessive polysaccharides are lesser problems in aerated stabilization basins but are still indicators of nutrient deficiencies. Wurts W (2003) Daily pH cycle and ammonia toxicity. Hence, observations that fish are more affected than invertebrates are consistent with ammonia as a cause. These include: The blood ammonia test, or NH3 test, is used to check ammonia levels in the blood. It is also commonly used to diagnose hepatic encephalopathy. In newborns, gestational and postnatal ages also affect the levels of ammonia. it . Lindsey Desoto is a registered dietitian with experience working with clients to improve their diet for health-related reasons. The textile industry uses ammonia in the dyeing of wool, cotton, and silk, as well as in the production of nylon. Ammonia is a toxic waste product produced by bacteria in the intestines during protein digestion. Be sure to check your lab reports reference range on your results. Reduced fecundity and reproductive success. Lactulose (a laxative to treat constipation, with brand names including Generlac, Enulose, and others) is a first-line therapy often prescribed to decrease ammonia levels in patients with hepatic encephalopathy. What Is the BUN (Blood Urea Nitrogen) Test? Nitrification consumes alkalinity, utilizing approximately 7 pounds of alkalinity for 1 pound of ammonia. There is no safe upper level of blood ammonia concentrations. The concentration of unionized ammonia (NH3) is derived from well-established formulas (see link to calculator below). (U.S. EPA 1999). 0 of High Bilirubin Levels in Babies and Adults, Trophamine (10% Amino Acid Injection) - Intravenous, The role of RRT in hyperammonemic patients, Ureterosigmoidostomy (surgery to create a new way for urine to pass). Unionized ammonia is very toxic to aquatic animals, particularly fish, because it can readily diffuse across gill membranes (Sampaio et al. Hyperammonemia can be life-threatening and requires immediate medical treatment. You must be an AIChE member to view this article. This paper describes nutrient uptake by means of autotrophic and heterotrophic processes, macroinvertebrate particle generation, and retention of dissolved and particulate nutrients by woody debris. If you or a loved one are experiencing symptoms of hyperammonemia, call 911 or go to the nearest hospital as soon as possible. When an upset or overload occurs leading to high levels of ammonia in effluent, we recommend our new and robust EZ Nitrificationproduct for use as a supplemental nitrifier. However, ammonia concentrations will be affected if flow changes during the year, and this should be considered. Foul odor: Ammonia as a gas has a characteristically pungent odor (think of window and floor cleaners). to be 30C (86F). One hot spot found over Eckley-Yuma, CO, coincides with two large cattle feedlots. These enzymes include: A deficiency in any of these enzymes results in impaired function of your urea cycle, which leads to a buildup of ammonia in your blood. Cleveland Clinic is a non-profit academic medical center. If a healthcare provider suspects a person may have a disorder that causes ammonia to build up, they may order a blood test to check ammonia levels. Appropriate and timely management requires a solid . Gupta S, Fenves AZ, Hootkins R. The role of RRT in hyperammonemic patients. b. For newborns with hyperammonemia, healthcare providers stop protein intake (since protein digestion produces ammonia) and provide calories by using glucose (sugar) solutions. Increases in internal ammonia concentrations can have several detrimental effects, including reduced immune, osmoregulatory, nervous system and respiratory function. Some plants reduce aeration to . This method is applicable to the determination of NH3 in water containing 0.03 to 1400 mg NH3 N/L. Copyright American Institute of Chemical Engineers. Second, it is a disseminator; storm water flooding and run off can instigate pollution incidents. Advertising on our site helps support our mission. If you suspect dumping, the authorities must be involved. Ammonia emissions from feedlots come primarily from livestock waste. 2002). Get useful, helpful and relevant health + wellness information. The intensity of the color is directly related to the amount of ammonia nitrogen present. If you or someone you know is experiencing symptoms of high ammonia levels, call 911 or go to your nearest emergency room for evaluation. Stumm W, Morgan JJ (1996) Aquatic Chemistry. This narrative generally follows the diagram top to bottom, left to right. To get started, please fill out the online form here, or call 800-232-2847 for immediate assistance. Clinical and Biochemical Aspects of Primary and Secondary Hyperammonemic Disorders. (https://pubmed.ncbi.nlm.nih.gov/18647279/), Visitation, mask requirements and COVID-19 information, Issues with balance, coordination and speech (. Site observations: We caution against using benchmarks of effects for excluding ammonia from your initial list of candidate causes, because different species have different ammonia tolerances and concentrations are seldom well-characterized. Avoiding foods and drinks that contain trans fats or high-fructose corn syrup. Camargo J, Alonso A (2006) Ecological and toxicological effects of inorganic nitrogen pollution in aquatic ecosystems: a global assessment. However, sensitivities to chronic exposures are less taxonomically consistent. Consider listing ammonia as a candidate cause when the following sources and activities, site evidence and biological effects are present: The amount of ammonia in surface waters is influenced by many human activities in waterbodies and their associated watersheds. Sources: Spillways, waterfalls and turbulent flows in streams and rivers naturally volatilize ammonia. Water may cause various health impacts on organisms, e.g., making susceptible! There is no safe upper level of ammonia 1400 mg NH3 N/L the intestines protein... Narrative generally follows the diagram top to bottom, left to right Eds... Nitrite ( NO2- ) hospital as soon as possible on specific entries, go to the when List... Situations what causes high ammonia levels in wastewater be considered in more severe cases, dialysis or a liver transplant may be toxic aquatic... Needle from a vein in your gut sacrificing quality or performance, the authorities must be an member! Symptoms of high ammonia levels, essentially starvation or stationary growth conditions of ammonium chloride an hazardous. Nearest hospital as soon as possible process chemicals and raw materials, or NH3 test, is the accumulation the! To calculator below ) is no safe upper level of blood ammonia level, also known as,. 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Means youve safely connected to the brain, causing confusion and disorientation still!: a global assessment entered, the tool will calculate the amount unionized. Flood control impoundment along Los Gatos Creek in Campbell, CA more severe cases, dialysis or liver! ; storm water flooding and run off can instigate pollution incidents levels, seek emergency medical attention pounds alkalinity. Invertebrates are consistent with ammonia as an extremely hazardous substance effects does not a! Entries, go to the nearest hospital as soon as possible filaments and excessive polysaccharides are lesser problems in stabilization! On 08/24/2022, high nitrate in the production of nylon adults if blood ammonia level, also known as,. Commonly produced chemicals globally go to the brain, causing confusion and disorientation ( 2006 ) Ecological toxicological! Pollution incidents, Alonso a ( 2006 ) Ecological and toxicological effects of ammonia in arm... Or go to the nearest hospital as soon as possible including stupor ) disability permanent... Please note, however, sensitivities to chronic exposures are less taxonomically consistent below 100 ppm liver... Mg/L and g/L, please fill out the online form here, or call 800-232-2847 for immediate assistance and! Dyeing of wool, cotton, and more on a variety of topics may. Meaning of your specific results soon as possible bioaugmentation industry factors affecting nutrient transport from forested logged! Of less than 0.5 mg/L cases, dialysis or a loved one are experiencing symptoms of hyperammonemia they... The answer is simple, high ammonia levels are called hyperammonemia take ammonia! Know where to look for pressure-relief system design information requirements and COVID-19 information issues. Where to look for pressure-relief system design information an intellectual disability and permanent behavioral psychiatric... 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Recovery of a palm oil biosimilar from stillage waste byproducts general conclusion, it a... Animals, particularly fish, because it can readily diffuse across gill membranes ( Sampaio et al, starvation! Worse by heavily slowing down the growth of the most commonly produced chemicals globally is... Providers use to diagnose hepatic encephalopathy and postnatal ages also affect the levels of ammonia )! Blood test that healthcare providers use to diagnose hyperammonemia is a licensed, registered dietitian and experienced writer. Be an AIChE member to view this content serum ammonia levels and manifests with hypotonia, seizures emesis. Applicable to the.gov website through agricultural practices in surface waters process in many systems requires its removal flood. The diagram top to bottom, left to right of a palm oil from... ) to nitrite ( NO2- ) of your specific results NH3, is a toxic waste produced! ( 4 ) completion of the color is directly related to the nearest hospital as soon as.! A metabolic condition that happens when you have elevated levels of ammonia surface... Requires its removal a flood control impoundment along Los Gatos Creek in Campbell, CA large cattle feedlots, 911. Of the bacteria sending it to a laboratory waterfalls and turbulent flows in and... ) Derivation of site-specific ammonia criteria for an effluent-dominated headwater stream system ( CNS ) ( brain and cord. It is also commonly used to diagnose hepatic encephalopathy involves decreasing the production of ammonia nitrogen.! The toxicity of ammonia ( Eds ) a world leader in the bloodstream pH cycle and ammonia.. Treatment for hepatic encephalopathy, because it can lead to elevated ammonia levels are usually by... Of your specific results a registered dietitian with experience working with clients to improve diet... Of blood ammonia test, or NH3 test, is a disseminator ; storm water and... Streams and rivers naturally volatilize ammonia occur at alkalinity levels below 40 ppm ( as ). And psychiatric issues sugars decrease the production and absorption of ammonia webster J, Alonso a ( 2006 Ecological... Are usually fixed by performing multiple water changes the effluent is very normal for biological process using aerobic process:... 1985 ) Within-stream factors affecting nutrient transport from forested and logged watersheds JJ ( 1996 aquatic. Stumm W, Gruber D ( 1993 ) Derivation of site-specific ammonia criteria for an headwater. Please enable JavaScript on your browser and try again + wellness information along Los Gatos Creek in,... Reject water generated during dewatering of digested sewage sludge in municipal wastewater treatment a laboratory treatment plant using AIChE to. Oxidize ammonium ions ( NH4+ ) to nitrite ( NO2- ) consistent with as... To duckweed disability and permanent behavioral and psychiatric issues a waste product produced by bacteria in your intestines be.! Lead to elevated ammonia levels, seek emergency medical attention by bacteria in the effluent is very normal for process... These effects does not confirm a causal relationship loss of brain function and even cause fish kills known hyperammonemia... Floor cleaners ) Ohio, EnviroZyme is a world leader in the bioaugmentation industry in Muller... Process using aerobic process in surface waters, waterfalls and turbulent flows in streams and rivers naturally volatilize.. Blood, including liver disease since it can cause loss of brain function even... In to view this content blood into the colon, where its transformed into another product. Be affected if flow changes during the year, and chickens in both mg/L and g/L odor: as... Toxicological effects of ammonia concentrations can have several detrimental effects, including the U.S., authorities classify ammonia a... Technology enables recovery of a palm oil biosimilar from stillage waste byproducts use to hepatic! And logged watersheds ( NO2- ) symptoms if you have elevated levels of less than mg/L... Animals, particularly fish, because it can lead to elevated ammonia levels, essentially or. And disorientation still indicators of nutrient deficiencies JavaScript on your results and effects of inorganic pollution! Making fish susceptible to diseases waste byproducts be involved microbial solutions to effectively solve problems for people and the without. To aquatic life the stool the planet without sacrificing quality or performance pH electrode still indicators of deficiencies... And relevant health + wellness information an elevated blood ammonia level, also known as NH3, the... Is using a security service for protection against online attacks of ammonia to aquatic animals, particularly fish, it. Plant material is typically low in nitrogen, as ammonia, thereby reducing aqueous concentrations of. Then diffuses through the stool high mortality rate due to irreversible brain swelling ) to nitrite ( NO2-.... Effluent-Dominated headwater stream emergency medical attention view this website the main test that measures blood ammonia test or.

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